The objective of this research was to prepare and evaluate buccal adhesive controlled release tablets of Diltiazem hydrochloride by direct compression method using Carbopol960p ,Guar gum and Xanthan gum as rate retardant polymers in concentration of 5%,15%,30%w/w. The formulations were evaluated for weight variation ,Hardness, %Friability, %Drug content, Mucoadhesive strength, surface pH and invitro drug release studies. Mucoadhesive strength was determined by the force of detachment in grams and was found to be between 17.67+0.141gm to 56.7+0.14gm and Surface pH was found to be 7. Invitro release studies revealed that as polymer concentration increases from 5% to 30%w/w, rate of drug release was retarded and the data was fitted into pharmacokinetic models. Among all other formulations, formulation (F5) containing 15%w/w of guar gum was found to be best as the release was retarded upto 8 hours and it follows zero order with non-fickian diffusion mechanism.
Loading....